pathway

Dna Methylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Dna Methylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

890Connections

0Hypotheses

3Analyses

40Outgoing

50Incoming

Summary

Dna Methylation is a biological pathway involved in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 496 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Dna Methylation
Summary	DNA methylation in the brain: epigenetic mechanisms, role in Alzheimer's disease, epigenetic clocks, and therapeutic targeting
Key Genes/Proteins	DNA, GENES, CANCER, INFLAMMATION
Related Diseases	Als, Cancer, Inflammation

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Wnt["Wnt"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Epigenetic["Epigenetic"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Mtor["Mtor"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Akt["Akt"]
    Dna_Methylation["Dna Methylation"] -->|"interacts"| Pi3K["Pi3K"]
    IDH1["IDH1"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    VEGFA["VEGFA"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    MDM4["MDM4"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    APOB["APOB"] -->|"therapeutic target"| Dna_Methylation["Dna Methylation"]
    style Dna_Methylation fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (111)

Target	Relation	Type	Str
Gene Expression	regulates	process	0.85
Anti-Inflammatory Gene Promoters	silences	gene	0.70
Wnt	interacts_with	pathway	0.55
Epigenetic	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
HEPATOCELLULAR CARCINOMA	expressed_in	disease	0.50
Cortex	associated_with	brain_region	0.50
FRONTAL	associated_with	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
MTOR SIGNALING	associated_with	concept	0.50
Neurodegenerative Diseases	inhibits	disease	0.50
Histone Modification	associated_with	process	0.50
Microbiota	regulates	process	0.50
Gut Microbiota	regulates	process	0.50
Histone Modification	interacts_with	process	0.50
Dna Repair	expressed_in	pathway	0.50
CYTOKINES	activates	concept	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
GENE EXPRESSION	activates	concept	0.50
disease	expressed_in	disease	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
Melanoma	expressed_in	disease	0.50
Cortex	expressed_in	brain_region	0.50
FKBP5	interacts_with	concept	0.50
Neuron	methylates	cell_type	0.50
Stem Cell	methylates	cell_type	0.50
Stem Cell	therapeutic_target	cell_type	0.50
Macrophage	therapeutic_target	cell_type	0.50
T Cell	therapeutic_target	cell_type	0.50
Macrophage	biomarker_for	cell_type	0.50
Hepatocyte	expressed_in	cell_type	0.50
T Cell	methylates	cell_type	0.50
Neuron	contributes_to	cell_type	0.50
Microglia	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Neuron	regulates	cell_type	0.50

Incoming (779)

Source	Relation	Type	Str
DNA	associated_with	gene	1.00
GENES	associated_with	gene	1.00
DNA	regulates	gene	1.00
Als	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
Cancer	expressed_in	disease	1.00
Cancer	regulates	disease	1.00
Als	regulates	disease	1.00
DNA	activates	gene	1.00
GENES	regulates	gene	1.00
CANCER	associated_with	gene	1.00
CANCER	regulates	gene	1.00
DNA	inhibits	gene	1.00
INFLAMMATION	regulates	gene	1.00
Inflammation	regulates	disease	1.00
Als	therapeutic_target	disease	1.00
CANCER	expressed_in	gene	1.00
APOPTOSIS	regulates	gene	1.00
Als	treats	disease	1.00
DNA	expressed_in	gene	0.90
GENES	therapeutic_target	gene	0.90
Cancer	therapeutic_target	disease	0.90
Als	expressed_in	disease	0.90
Aging	associated_with	disease	0.90
Tumor	therapeutic_target	disease	0.90
Tumor	regulates	disease	0.90
DNA	implicated_in	gene	0.90
PSME2	correlates_with	gene	0.85
DNMT3A	catalyzes	gene	0.80
Tumor	associated_with	disease	0.80
Tumor	expressed_in	disease	0.80
GENES	expressed_in	gene	0.80
ALZHEIMER'S DISEASE	associated_with	gene	0.80
CANCER	therapeutic_target	gene	0.80
OXIDATIVE STRESS	regulates	gene	0.80
MICRORNAS	regulates	gene	0.80
AUTOPHAGY	regulates	gene	0.80
GENES	inhibits	gene	0.80
CANCER	inhibits	gene	0.80
AGING	associated_with	gene	0.80
ALZHEIMER	associated_with	gene	0.80
DNA	therapeutic_target	gene	0.80
INFLAMMATION	associated_with	gene	0.80
Inflammation	associated_with	disease	0.80
OVERVIEW	treats	gene	0.80
DNA	causes	gene	0.80
Cancer	inhibits	disease	0.75
GAIN	associated_with	gene	0.70
MTOR	associated_with	gene	0.70
Carcinoma	expressed_in	disease	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Dna Methylation

Understanding Entity Pages

Summary

Wiki Pages (21)

DNA Methylation

Neuroresilience Mechanisms and Evidence

NPM1 Gene

NRF2 Oxidative Stress Pathway

NTF4 Protein

TREM2 Mechanism Hub

Pathway Diagram

Outgoing (111)

Incoming (779)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Epigenetic reprogramming in aging neurons

Related Papers (0)

Dna Methylation

Understanding Entity Pages

Summary

Wiki Pages (21)

DNA Methylation

Neuroresilience Mechanisms and Evidence

NPM1 Gene

NRF2 Oxidative Stress Pathway

NTF4 Protein

TREM2 Mechanism Hub

Mitochondrial Dysfunction in Parkinson's Disease

Oligodendrocytes

APOC4 — Apolipoprotein C-IV

nf1-protein

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Epigenetic Alterations in Alzheimer's Disease

Pre-symptomatic Conversion Windows in ALS Genetic Risk Carriers

Ferroptosis in Alzheimer's Disease

Tauopathies

NPAS3 Gene

PEN2 Gene

RNA Metabolism Dysregulation in Alzheimer's Disease

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Liquid Biopsy Diagnostics for Corticobasal Syndrome

Pathway Diagram

Outgoing (111)

Incoming (779)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Investigate mechanisms of epigenetic reprogramming in aging neurons, including D

Epigenetic reprogramming in aging neurons

Related Papers (0)